KMID : 0387420080190030055
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Korean Society of Oriental Neuropsychiatry 2008 Volume.19 No. 3 p.55 ~ p.68
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The Effects of OJaJiHwangEumJa(OJJHEJ) Hot water extract & Ultra-fine Powder on Proinflammatory Cytokine of Microglia and Memory Deficit Model
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Kim Seok-Hwan
Lee Sang-Ryong
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Abstract
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Background: Microglia produces a barrage of factors (IL-l, TNF-, NO, superoxide) that are toxic to neurons and playa major role in the cellular immune response associated with the pathology of Alzheimer¡¯s disease(AD). OJaJiHwangEumJa(OJJHEJ) has been usually used for the treatment of senile disorders. For enhancing efficacy and convenience, the change of the drug delivery device of oriental herbal medicine is required.
Objective: This experiment was designed to investigate the effect of the OJJHEJ hot water extract & ultra-fine powder on proinflammatory cytokine of microglia and memory deficit model.
Method: The effects of the OJJHEJ hot water extract on production of IL-1, IL-6, TNF-, in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the OJJHEJ hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine and AChE in serum of the memory deficit mice induced by scopolamine were investigated.
Results: 1. The OJJHEJ hot water extract suppressed the production of IL-1, IL-6, TNF- in BV2 microglial cell line and the production of IL-6 was suppressed significantly. 2. The OJJHEJ hot water extract & ultra-fine powder decreased AChE significantly in the serum of the memory deficit mice induced by scopolamine. 3. The OJJHEJ hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze.
Conclusions: This experiment shows that the OJJHEJ hot water extract & ultra-fine powder might be effective for the prevention and treatment of memory impairment diseases. Investigation into the clinical use of the OJJHEJ hot water extract & ultra-fine powder for Alzheimer¡¯s disease is suggested for future research.
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KEYWORD
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Microglia, OJaJiHwangEumja(OJJHEJ), Hot water extract & Ultra-fine powder
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